Explore how human brain organoids use BDNF and NMDA modulation to enable synaptic plasticity, LTP, and adaptive learning in CNS drug discovery models.

Discover how human iPSC-derived 3D cortical organoids enable high-throughput screening for neural modulators, improving CNS drug discovery with human-relevant models.

Explore how a human iPSC-derived 3D brain microphysiological system models neurological disease and toxicity—offering advanced insights into synaptic activity and myelination.

Explore how rotenone exposure affects human brain development using a reproducible iPSC-derived 3D brain model that highlights early-stage neurotoxicity.

A novel approach to neurotoxicity screening using iPSC-derived 3D neural cultures. Learn how calcium oscillation analysis enables high-throughput identification of neurotoxic compounds.

Technology integrates induced pluripotent stem cell (iPSC)-derived neurons and primary human Schwann cells, forming a functional 3D nerve model capable of electrophysiological and morphological assessments.

Explore how 3D hiPSC-derived neurospheroids outperform 2D models in predicting seizurogenic risk. This study highlights a reproducible, human-relevant approach for neurotoxicity screening in drug development.

Study demonstrated superior likelihood ratios (LR+ and iLR-), indicating better reliability for clinical neurotoxicity predictions.

Discover how paroxetine, a common SSRI, affects human brain development using a 3D iPSC-derived brain model. This study reveals critical neurodevelopmental disruptions at therapeutic doses.