Publications

Featured Publications

Publications Library

Screening for Modulators of Neural Network Activity in 3D Human iPSC-Derived Cortical Spheroids
Discover how human iPSC-derived 3D cortical organoids enable high-throughput screening for neural modulators, improving CNS drug discovery with human-relevant models.
A Human Brain Microphysiological System Derived from Induced Pluripotent Stem Cells to Study Neurological Diseases and Toxicity
Explore how a human iPSC-derived 3D brain microphysiological system models neurological disease and toxicity—offering advanced insights into synaptic activity and myelination.
Rotenone Exerts Developmental Neurotoxicity in a Human Brain Spheroid Model
Explore how rotenone exposure affects human brain development using a reproducible iPSC-derived 3D brain model that highlights early-stage neurotoxicity.
Functional and Mechanistic Neurotoxicity Profiling Using Human iPSC-Derived Neural 3D Cultures
A novel approach to neurotoxicity screening using iPSC-derived 3D neural cultures. Learn how calcium oscillation analysis enables high-throughput identification of neurotoxic compounds.
Engineering a 3D functional human peripheral nerve in vitro using the Nerve-on-a-Chip platform
Technology integrates induced pluripotent stem cell (iPSC)-derived neurons and primary human Schwann cells, forming a functional 3D nerve model capable of electrophysiological and morphological assessments.
Comparative Assessment of Ca²⁺ Oscillations in 2- and 3-Dimensional hiPSC-Derived and Isolated Cortical Neuronal Networks
Explore how 3D hiPSC-derived neurospheroids outperform 2D models in predicting seizurogenic risk. This study highlights a reproducible, human-relevant approach for neurotoxicity screening in drug development.
Assessment of a 3D Neural Spheroid Model to Detect Pharmaceutical-Induced Neurotoxicity
Study demonstrated superior likelihood ratios (LR+ and iLR-), indicating better reliability for clinical neurotoxicity predictions.
Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model
Discover how paroxetine, a common SSRI, affects human brain development using a 3D iPSC-derived brain model. This study reveals critical neurodevelopmental disruptions at therapeutic doses.
Altered Network and Rescue of Human Neurons Derived from Individuals with Early-Onset Genetic Epilepsy
Discover research on CDKL5 deficiency disorder, highlighting neural network disruptions and potential treatments for early-onset genetic epilepsy.