Explore how a human iPSC-derived 3D brain microphysiological system models neurological disease and toxicity—offering advanced insights into synaptic activity and myelination.

Explore how rotenone exposure affects human brain development using a reproducible iPSC-derived 3D brain model that highlights early-stage neurotoxicity.

A novel approach to neurotoxicity screening using iPSC-derived 3D neural cultures. Learn how calcium oscillation analysis enables high-throughput identification of neurotoxic compounds.

Technology integrates induced pluripotent stem cell (iPSC)-derived neurons and primary human Schwann cells, forming a functional 3D nerve model capable of electrophysiological and morphological assessments.

Explore how 3D hiPSC-derived neurospheroids outperform 2D models in predicting seizurogenic risk. This study highlights a reproducible, human-relevant approach for neurotoxicity screening in drug development.

Study demonstrated superior likelihood ratios (LR+ and iLR-), indicating better reliability for clinical neurotoxicity predictions.

Discover how paroxetine, a common SSRI, affects human brain development using a 3D iPSC-derived brain model. This study reveals critical neurodevelopmental disruptions at therapeutic doses.

Discover research on CDKL5 deficiency disorder, highlighting neural network disruptions and potential treatments for early-onset genetic epilepsy.

Explore 3D neuronal microphysiological systems (MPS) for modeling the human nervous system. Learn how to use brain organoids, myelination, and functional neural networks for preclinical drug testing and disease modeling.

A novel high-throughput screening platform using iPSC-derived cortical neural spheroids to assess neuroactive compounds via calcium signal analysis.