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Nerve-On-A-Chip for Modelling Motor Neuron Diseases and Preclinical Neurotoxicity Testing
A 3D microphysiological model designed to mimic motor neuron diseases, enabling robust nerve growth analysis, glial interactions, and preclinical neurotoxicity testing.
Modeling Chemotherapy-induced Peripheral Neuropathy using a Nerve-on-a-Chip Microphysiological System
This study assesses the impact of four chemotherapy drugs on nerve function using electrophysiology, metabolic assays, and histology.
Improving the Stability and Reproducibility of Clinical Neurotoxicity Predictions from a High-throughput Compatible Neural Organoid Platform
Discover how automated analysis pipelines enhance the stability and reproducibility of clinical neurotoxicity predictions using a high-throughput cortical organoid platform.
Identification of a Potential Therapeutic Compound for Rett Syndrome Using a Highly Homogenous Human iPSC-derived Cortical Organoid Screening Platform
A human iPSC-derived cortical organoid platform, designed for high-throughput, reproducible compound screening.
Glial Cell Type Composition in a 3D Model of the Central Nervous System
Evaluate glial cell differentiation within a 3D central nervous system (CNS) model using induced pluripotent stem cell (iPSC)-derived neurons.
Evaluating Human Nerve Conduction Velocity In Vitro as a Novel Metric for Assessing Chemotherapeutics-induced Peripheral Neuropathy
In vitro nerve conduction velocity (NCV) testing for evaluating chemotherapy-induced peripheral neuropathy.
Development of Rat DRG Model for Predicting Peripheral Neuroinflammation and Neurotoxicity of Therapeutic Agents
Discover Takeda's innovative rat DRG-microglia co-culture model designed to predict peripheral neuroinflammation and neurotoxicity in therapeutic agents.
Development of an In Vitro Human-derived 3D Model of Dorsal Horn Pain Signaling
3D in vitro model mimicking the dorsal root ganglion (DRG) to dorsal horn synapse using human iPSC-derived sensory nerves.
Development of a High-Content Human Co-culture Model to Investigate Chemotherapy-Induced Peripheral Neuropathy
Learn how to evaluate chemotherapy-induced peripheral neuropathy and antibody-drug conjugate effects on sensory neurons and Schwann cells.