Applications

Neuroinflammation

Evaluate anti-inflammatory drug efficacy in a functional human neuroimmune model. CNS-3D Inflammatory Organoids incorporate neurons, astrocytes, and microglia to model inflammatory activation, measure downstream neural impact, and prioritize candidates that reduce inflammatory injury.

Model Neuroinflammatory Disease Biology

Neuroinflammatory disease biology is driven by complex interactions between microglia, astrocytes, and neurons. CNS-3D Inflammatory Organoids provide a reproducible human 3D model for investigating how inflammatory stimuli alter neuroimmune activation, cytokine response, tissue health, and neuronal network function.

As the only commercially available 3D brain organoid model incorporating microglia, CNS-3D Inflammatory Organoids enable mechanistic disease modeling and anti-inflammatory efficacy testing in a human cortical tissue context. Integrated endpoints spanning immunostaining, cytokine analysis, cytotoxicity, gene expression, and functional calcium imaging quantify inflammatory response and drug efficacy.

Advantages

Quantify inflammation, injury, and neural impact.

Study inflammatory mechanisms and anti-inflammatory efficacy in a reproducible human 3D CNS model containing neurons, astrocytes, and microglia.

Immunocompetent 3D Brain Model

The only commercially available 3D brain model incorporating microglia.

Human Neuroimmune Biology

Study inflammatory responses across neurons, astrocytes, and microglia.

Functional Neural Impact

Measure inflammation-driven changes in neuronal network activity alongside immune and glial response.

Multiplexed Efficacy Endpoints

Quantify drug effects across cytokines, cytotoxicity, imaging, molecular, and functional endpoints.

Use Case

Neuroinflammation

Recapitulate hallmarks of neuroinflammation—including microglial activation, pro-inflammatory cytokine release, and disruption of neuronal network activity—with CNS-3D Inflammatory Organoids.

By administering pro-inflammatory stimuli such as TNF-α, LPS, or IL-6, researchers can investigate neuroinflammatory disease mechanisms to inform target pathway selection and identify endpoints for downstream anti-inflammatory efficacy testing.

LPS stimulation increases microglial and astrocyte signal in CNS-3D Inflammatory Organoids, as shown by IBA1 and GFAP staining under control and inflammatory conditions.

Use Case

Anti-Inflammatory Efficacy

Prioritize anti-inflammatory candidates by measuring their ability to reduce inflammatory injury. By co-administering drug candidates with a pro-inflammatory stimulus, researchers can compare treatment effects on inflammatory response, cell health, and neuronal network function to identify candidates with stronger protective activity.

TNFα-induced LDH release enables comparison of anti-inflammatory candidate effects on cytotoxicity, distinguishing treatments with stronger protective activity.

Offerings

Products & Services

Investigate neuroinflammation with assay-ready products for in-house studies or through CNS Services for end-to-end study design, execution, and analysis.

CNS-3D Inflammatory
Organoids

The only assay-ready immunocompetent brain organoid model to study neuroinflammatory mechanisms and drug efficacy. Available in 24-, 48-, 96-, and 384-replicate formats.

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CNS Services

Study design, execution, and analysis across CNS safety and efficacy applications. Choose from established assay workflows or partner with our team to design studies around your specific research question.

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Resources

Neuroinflammation Resources

View resources for studying neuroinflammatory mechanisms and drug efficacy in CNS-3D Inflammatory Organoids.

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