The Endurance Study is a retrospective, non-interventional study evaluating the predictive performance of CNS-3D Brain Organoids in small molecules with documented human clinical outcomes from 120,551 patients and known positive controls. The study focuses on seizure liability, one of the most challenging and regulatory-critical CNS adverse effects to predict in neurological drug development.

Top-line data shows 83% sensitivity and 89% specificity in predicting clinical seizure liability across seizure-inducing drugs and clinically safe drugs, outperforming animal models with a 13x higher predictive performance¹.

‍

References

¹Wang, et al. Assessment of a 3D neural spheroid model to detect pharmaceutical induced neurotoxicity. ALTEX. 2022; 39(4):560–582.