Meeting Overview
The 2nd ADC conference focused on improving the prediction and translation of antibody-drug conjugate (ADC) toxicities to enhance tolerability and therapeutic indices. Attendees will engage with leading minds in ADC toxicology through case-study-led presentations, interactive discussions, and workshops aimed at addressing translational challenges and off-target toxicities.
Poster
High-throughput Functional and Morphological Neurotoxicity Screening in Human NerveSim
- AxoSim has developed a novel microphysiological human Nerve-on-a-Chip system, or NerveSim®, comprised of an iPSC-derived neuron and primary human Schwann cell 3D coculture system that forms a morphological and electrophysiological simulacrum of a human nerve.
- This system is employed in a 24-well Embedded Electrode Array (EEA) culture plate to provide high-throughput electrophysiological characterization amenable to testing multi-drug panels for neurotoxicity on a clinically relevant nerve model.
- We tested several chemotherapeutic compounds with known neurotoxicities by correlating changes in compound action potentials (CAPs) and axonal morphology for multidimensional non-invasive longitudinal functional characterization.
