Longitudinal Functional Profiling of Human Brain Organoids with High-Throughput Calcium Imaging

July 22, 2026 | 8:00 AM PT / 11:00 AM ET / 5:00 PM CEST

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In this joint webinar, scientists from 28bio and Curi Bio will present a collaborative study combining 28bio CNS-3D Brain Organoids with the Curi Bio Nautilai Plus™ high-content imaging platform and Pulse™ analysis software. The study demonstrates how high-throughput calcium imaging can generate quantitative dose-response profiles and enable longitudinal assessment of brain organoid function across 7 days.
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Key Takeaways

28bio CNS-3D Brain Organoids are human iPSC-derived, assay-ready 3D cortical organoids that contain neurons and astrocytes and display spontaneous calcium activity.

Curi Bio Nautilai Plus is a high-content imaging platform engineered to capture rapid fluorescent signals from 2D and 3D in vitro models for quantitative analysis of dynamic cellular function.

Together, CNS-3D and Nautilai help translate complex 3D neural activity into decision-ready insights for neuroactive compound screening, functional neurotoxicity assessment, and longitudinal response characterization.

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Speakers

Nicholas Coungeris, Research Scientist II at 28bio

Nick Coungeris is a Research Scientist II at 28bio with over 10 years of experience developing human iPSC-based neural models. His work focuses on advancing 28bio CNS-3D Technology for neurotoxicity prediction, disease modeling, and efficacy testing, including the recent development of inflammatory brain organoid models for Alzheimer’s disease and related neurodegenerative disorders.

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Thomas Leahy, PhD,Field Applications Manager at Curi Bio

Dr. Leahy is a Field Applications Scientist at Curi Bio with a background in musculoskeletal and cardiovascular research, biomechanics, and 3D tissue engineering. He supports the adoption of Curi Bio’s technologies by collaborating with internal scientists and partnering directly with customers to expand applications across cardiac, skeletal muscle, and neuromuscular research.