SOT 2026

Meet us at the Society of Toxicology Annual Meeting, where we’ll be showcasing how human CNS and PNS organoids can be used to predict neurological risk in preclinical safety programs.

At our booth, you’ll see how functional neural endpoints—including changes in neuronal firing, synaptic signaling, and network behavior—enable detection of functional neurological effects before overt toxicity is observed. These human-relevant readouts provide deeper insight into neurological liability and support more informed dose selection and safety margin decisions.

If you’re evaluating new approaches to strengthen neurological risk assessment or complement existing workflows, we’d love to connect. Schedule a meeting with our team during SOT to discuss how functional CNS and PNS models can fit into your preclinical strategy.

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Exhibitor Workshop

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Wednesday, March 25: 3:15 PM–4:15 PM | Room 23B

Cross-modality Neurotoxicity Prediction Using Human CNS-3D Organoids and Machine Learning
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Accurate neurotoxicity prediction remains a key challenge in drug development. To validate CNS-3D Brain Organoids as a preclinical neurotoxicity model, 150 small molecules and a set of ASOs were assessed using functional neurophysiological endpoints and analyzed with an XGBoost machine-learning model. Across this dataset, CNS-3D showed significantly improved sensitivity and specificity relative to animal models, supporting their use for clinically predictive neurotoxicity assessment.

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Poster Sessions

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Tuesday, March 24, 1:45 PM-415 PM | Poster #4161
Neurotoxicity and Hepatotoxicity Testing in Organotypic Models as Part of a Tiered Screening Assessment for Force Health Protection
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Session: New Approach Methods: In Vitro III

Presenter: Andrew Keebaugh, PhD, DABT, AV, Inc. contracted to the Air Force Research Laboratory

AFRL-2025-5586, 11 Dec 2025.

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Wednesday, March 25, 1:45 PM-4:15 PM | Poster #5048
CNS-3D Functional Organoids Predict Clinical Neurotoxicity Outcomes for Small Molecules and Anti-sense Oligonucleotides presented by 28bio
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Wednesday, March 25, 1:45 PM-4:15 PM | Poster #5046
The Advantages of CNS-3D Organoids for Functional Neuromodulation Studies presented by 28bio
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Schedule a Meeting

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