SPS 2026

Safety Pharmacology Society Annual Meeting 2026

September 21-23, 2026 | Montreal, Canada | Booth #17

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28bio will be at the Safety Pharmacology Society Annual Meeting, September 21–23 in Montreal, held jointly with the Canadian Society of Pharmacology and Therapeutics.  

This year's program places heavy emphasis on CNS safety pharmacology and New Approach Methodologies (NAMs), with dedicated sessions including "New Frontiers in Neuropharmacology: Integrating PK, Neuropathology, NAMs, AI & Safety Pharmacology Case Studies" and "CNS Safety Pharmacology in the NAMs Era: Addressing Risk for Novel Modalities."  

If you are interested in incorporating CNS and PNS organoids into your safety pharmacology programs, be sure to stop by one of our presentations and schedule time to meet with a 28bio team member.

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Partner Talk‍

Session Title: Human CNS-3D organoids predict clinical seizure liability

Date & Time: Tuesday, September 22, 2026 | 12:30—13:30

Room: Salon Cartier II

Session Description: A retrospective drug panel of 66 small-molecule drugs was assembled from human clinical evidence, including 30 seizure-associated drugs and 36 comparator drugs without documented clinical seizure liability. Drugs were tested across concentration ranges anchored to reported clinical Cmax, and calcium time-series responses were integrated with chemical structure features using a machine-learning workflow. The final model predicted clinical seizure liability with an AUROC of 0.872, achieving 83.3% sensitivity and 88.9% specificity in drug-level cross-validation. Model scores also stratified seizure-associated drugs by clinical context and prevalence, suggesting that CNS-3D activity profiles capture clinically meaningful differences in seizure risk.

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Poster Presentations
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• CNS-3D functional organoids predict clinical neurotoxicity outcomes for small molecules
• ASO neurotoxicity prediction using CNS-3D functional organoids
• Integrated Assessment of AAV Transduction, Functional Impact, and Toxicity in CNS-3D Brain Organoids‍‍
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We look forward to meeting you.