This on-demand webinar presents advancements in in vitro modeling for neurotoxicity testing and drug discovery, with a focus on human-relevant platforms that reduce reliance on animal models. Experts from Johns Hopkins University and 28bio share the development and application of the Nerve Sim and Brain Sim platforms—two powerful tools designed to simulate in vivo nerve and brain functionality with high reproducibility.
Learn how the Nerve Sim platform enables electrophysiological testing, supports research into rare diseases and neuropathies, and offers clinically relevant insights for nerve conduction studies. The session also explores the creation of human nerve models and validated assays for chemotherapeutic toxicity. The Nerve-on-a-Chip model is introduced as a transformative step forward in replicating human nerve structure and function.
The webinar also covers the Brain Sim platform, a mini brain model with broad applications in neurological drug discovery. Highlights include the integration of patient-derived iPSCs, the evaluation of gene therapies, and new findings on the neurological impact of SARS-CoV-2.
Lowry Curley, PhD
Helena Hogberg, PhD
Deputy Director, Center for Alternatives to Animal Testing, Johns Hopkins Bloomberg School of Public Health
